Targeting the long non-coding RNA HHIP-AS1 in sonic hedgehog driven brain tumors

Aberrant activation of the sonic hedgehog (SHH) pathway is one of the key drivers of tumorigenesis in aggressive pediatric brain tumors. However, SHH pathway inhibitors for the treatment of brain tumors demonstrated only limited responses indicating that a better knowledge of the regulators of the SHH pathway is needed. To determine the contribution of long non-coding RNAs (lncRNAs), which play an important role in tumorigeneses, in SHH-driven brain tumors, we analyzed the transcriptome of several thousand normal and neoplastic tissues with and without SHH activation. We identified the long non-coding RNA Hedgeh…