Annular Migratory Rash In a Newborn Related to Prostaglandin E1 Infusion: A Case Report
Buse Önen Ocak, Refika Sirma Dokuzboy, Hayriye Gözde Kanmaz Kutman · Zeitschrift für Geburtshilfe und Neonatologie · 2025 · Heft 05 · S. 373-375
Bibliografische Angaben
Zusammenfassung
AbstractProstaglandin E1 (PGE1, alprostadil) is essential in managing ductus-dependent congenital heart defects (CHD) in neonates. Although its common adverse effects are well documented, dermatologic manifestations remain rare and underrecognized. We report a term male neonate with a prenatal diagnosis of complex critical CHD who required PGE1 infusion and subsequently developed an annular migratory rash on the third postnatal day. The rash resolved within minutes of PGE1 dose reduction but recurred upon dose escalation, strongly suggesting a causal link. Following surgical palliation and discontinuation of PGE…
