CareLit Fachartikel

Cyclic AMP and anionic currents in porcine ciliary epithelium

Johannes C. Fleischhauer, Jean-Louis Bény, Josef Flammer, Ivan O. Haefliger · Klinische Monatsblätter für Augenheilkunde · 2001 · Heft 05 · S. 370-372

Dokument
959564
CareLit-ID
Jahr
2001
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Monatsblätter für Augenheilkunde
Autor:innen
Johannes C. Fleischhauer, Jean-Louis Bény, Josef Flammer, Ivan O. Haefliger
Ausgabe
Heft 05 / 2001
Jahrgang 218
Seiten
370-372
Erschienen: 2001-01-01 00:00:00
ISSN
0023-2165
DOI
10.1055/s-2001-15903

Zusammenfassung

Abstract INTRODUCTION To investigate whether in the ciliary epithelium of isolated porcine ciliary body cyclic 3′,5′ adenosine monophosphate (cAMP) activates transmembrane anionic currents. METHODS Changes in membrane potential induced either by the adenylcyclase activator forskolin (10 μM; n=4) or the stable membrane permeable cAMP analog 8-bromo-adenosine 3′,5′-cyclic monophosphothioate (8-br-cAMP; 30 μM; n=4) were measured with intracellular microelectrodes. The effect of the drugs were assessed in the absence or in the presence of the non-selective anionic channel/transporter inhibitor diisothiocyanatostilbe…

Schlagworte

Kammerwasserproduktion Chloridkanäle Elektrophysiologie Augeninnendruck Glaukom transepithelialer Wassertransport Aqueous humor formation chloride channels electrophysiology intraocular pressure glaucoma transepithelial water transport Adenosine Adenosine Monophosphate 8-Bromo-cAMP Adenylcyclase