CareLit Fachartikel
YB-1 mediates IFN-γ dependent regulation of TGF-β responsive genes, thereby providing antifibrotic effects
HM Said, A En-Nia, P Mertens, AM Gressner, S Dooley · Zeitschrift für Gastroenterologie · 2004 · Heft 02
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961787
CareLit-ID
Jahr
2004
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Zusammenfassung
Hepatic stellate cells (HSC) are the main producers of type I collagen (Col1) in normal and cirrhotic liver. The function of TGF-b as profibrogenic cytokine and inducer of collagen expression has been exploited in TGF-b antagonizing strategies to experimentally reduce collagen content and fibrogenesis. In HSC, Smads3/4 mediate the TGF-b effect to the collagen promoter, which can be abrogated in vitro and in vivo by inhibitory Smad7. In various cell types, Y-box protein 1 also interferes with the collagen promoter and represses collagen synthesis. In activated HSC, overexpression of YB-1 resulted in repression of…
Schlagworte
IFN-γ
TGF-β
YB-1
antifibrotic effects
collagen
fibrogenesis
Zeitschrift für Gastroenterologie
