The interleukin-10 receptor 1 (IL-10R1) G330R allele is associated with advanced fibrosis in chronic HCV-1 infection

Introduction: Immune response to viral infection is an important determinant of liver injury in chronic hepatitis C (CHC). In this respect, the natural history of CHC is influenced by the immunogenetic background of affected individuals. IL-10 is a cytokine that exerts a variety of immunoregulatory activities and experimental data suggest a protective role of IL-10 in hepatic fibrogenesis. Administration of rhIL-10 in patients with CHC reduces hepatic inflammation and fibrosis. Aim of the study was to investigate the impact of two functionally important coding SNPs of the IL-10R1, S138G (SNP3) and G330R (SNP4),…