Metachronous mucosa-associated lymphoid tissue (MALT) lymphoma and adenocarcinoma of the stomach (case report)

Patient and methods: A 69 year-old woman was diagnosed and successfully treated for MALT lymphoma by conservative (non-surgical) method 4 years earlier. Helicobacter pylori eradication therapy and combined cytostatic treatment was conducted. Close follow-up by repeated upper gastrointestinal endoscopy showed complete regression of lymphoma however, revealed a benign-looking ulcer (1.5cm in diameter) in the distal part of the stomach. Biopsies were obtained from the relatively normal looking mucosa and the margin of the ulcer. Proton-pump inhibitor therapy was initiated. Histopathology of biopsy revealed cellular…