Gastrointestinal manifestations of common variable immunodeficiency

Background: Discovery of multiple gastrointestinal polyps using endoscopy indicate the presence of inherited polyposis sy, however, they can also be associated to noninherited polyposis sy, such as nodular lymphoid hyperplasia (NLH). NLH can be the manifestation of common variable immunodeficiency, a syndrome characterized by immature B lymphocytes, that recognize and proliferate in response to antigens, but fail to differentiate to become plasma cells. This abortive differentiation pattern leads to panhypogammaglobulinemia and recurrent inflammations. We present a case report illustrating gastrointestinal manif…