Cellular immunotherapy in late stage breast cancer patients with reactivated autologous Memory T-cells (MTC) derived from bone marrow (BM) (Phase-I trail)
K Ehlert, P Beckhove, IJ Diel, V Schirrmacher, A Schneeweiss, G Bastert, HJ Strittmatter, F Schuetz · Zentralblatt für Gynäkologie · 2004 · Heft 06
Bibliografische Angaben
Zusammenfassung
We have previously shown an enrichment of tumor-specific MTC in BM in 66% of breast cancer patients by using ELISpot-analysis. Upon specific restimulation with dendritic cells (DC) in vitro BM T cells exert specific effector functions like IFN-gamma production and cytotoxicity. Furthermore we have shown in NOD/Scid-mice that reactivated MTC are able to kill tumor cells by induction of apoptosis (Nature Med, 2001). This effect required appropriate stimulation by tumor associated antigens (TAA), since MTC stimulated with irrelevant antigen did not exert anti-tumor effects in vivo. Furthermore we were able to show…
