TGF-beta suppresses tumor progression in colon cancer by inhibition of IL–6 trans-signaling
C Becker, MC Fantini, C Schramm, HA Lehr, S Wirtz, A Becker, J Burg, S Strand, R Kiesslich, S Huber, PR Galle, M Blessing, S Rose-John, MF Neurath · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Colorectal cancer is one of the most common fatal malignancies worldwide., with an incidence second only to lung cancer. However, the molecular pathogenesis of colorectal cancer is still poorly understood. Several lines of evidence suggest an important role of TGF-beta signaling in cancer development, although the molecular and immunological mechanisms are largely unknown. We have analyzed the role of TGF-beta signaling in a murine model of colon carcinoma. In the present manuscript we provide evidence that TGF-beta signaling in infiltrating CD4+ T cells is important to control the growth of dysplastic epithelia…
