Vascular Endothelial Growth Factor D (VEGF-D) is a novel Independent Prognostic Marker for Survial in Gastric Cancer
S Jüttner, C Wißmann, T Jöns, M Vieth, W Haensch, S Gretschel, PM Schlag, W Kemmner, M Höcker · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: The angiogenic factor VEGF-D and its close homologue VEGF-C are ligands for VEGF receptor 3 (VEGFR–3/flt4) and have been implicated in lymphatic development and metastases. The pathobiological role of VEGF-D in gastric cancer, whose clinical outcome is critically determined by its lymphatic spread, however, is unclear. Aim: Characterization of VEGF-D, VEGF-C and VEGFR–3 expression in gastric adenocarcinomas and correlation of findings with clinicopathological characteristics. Methods: VEGF-D, VEGF-C and VEGFR–3 were detected by immunohistochemistry (IHC), real time RT-PCR and/or in situ hybridization in R0…
