Origin and Spread of Periinfarct Depolarization in Rats Detected by ECoG and MEG

The knowledge about the origin and the spatio-temporal pattern of propagation of spreading depolarization (SD) after focal ischemic brain infarction is limited. Using the information of the simultaneously recorded ECoG and MEG it seems possible to describe the localization of underlying neurophysiological processes. We investigated in 8 rats 32 periinfarct depolarizations by simultaneously recorded ECoG and MEG. The ECoG was recorded by a grid of 4×4 electrodes with a spatial distance of 1.25mm between adjacent electrodes. The MEG was recorded by a 16-channel Micro-SQUID system built at the Biomagnetic Center (1…