Non-invasive „phenotyping“ of Spinocerebellar Ataxia type 3 (SCA3)
AH Jacobs, A Thomas, L Schöls, M Abele, J Kessler, E Kalbe, O Lenz, R Hilker, J Rudolf, T Klockgether, WD Heiss · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: SCA6 is a channelopathy confined to the cerebellum, while SCA3 is a trinucleotide disease that is generalized throughout many brain regions. Together, they account for more than 60% of spinocerebellar ataxias in Germany. By positron emission tomography (PET), we sought to investigate the specific patterns of cerebral glucose metabolism and benzodiazepine receptor binding in SCA3 and SCA6 which might be characteristic for the respective disease. Patients/Methods: Multitracer PET imaging ([18F]FDG, [11C]FMZ) and MRI were performed in patients with SCA3 (n=8, mean age 52.6±10.3 years) and SCA6 (n=7, 53±…
