The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
N Kleczar, S Farmand, A Härle, H Pels, K Fließbach, I Schmidt-Wolf, A Glasmacher, H Kölsch, M Linnebank, U Schlegel · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. The human methionine-homocysteine metabolism is important for genomic integrity due to a key position in folate-dependent DNA methylation and synthesis. We have previously suggested a protective function of the functional polymorphism methionine synthase c.2756A>G (D919G) against the incidence of primary central nervous system lymphoma (Brit J Cancer, in press). Here we present a confirmation of the assumed association by the analysis of an extended patient sample. In total, 43 PCNSL patients were compared to 142 age and sex…
