A Serum Proteom Approach to Diagnose Liver Fibrosis/Cirrhosis – Preliminary Results

Well known limitations of liver biopsies to diagnosis and monitoring liver fibrosis/cirrhosis necessitate non-invasive methods, e.g. the determination of reliable serum parameters. A promising approach to non-invasive biomarker discovery in biological fluids is serum protein profiling using SELDI-based ProteinChip® technology as a powerful method to comparatively study protein expression. It has been previously demonstrated that this technique can discover and validate biomarkers of diagnostic relevance from biological fluids(1). The goal of this study is the exemplary Expression Difference MappingTM of ten seru…