TGFB1 and decorin induced extracellular matrix protein production of hepatic stellate cells and myofibroblasts
G Firneisz, J Dudás, B Saile, T Szarvas, G Lengyel, Z Tulassay, J Fehér, I Kovalszky, G Ramadori · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and aims: Studies suggested that decorin might act as an inhibitory agent of fibrogenesis in experimental glomerulonephritis. We hypothetised a simliar decorin effect in the liver on hepatic stellate cells (HSC) and myofibroblasts (MF), possibly via the inhibition of TGFB1 effect using the MAPK signal-transduction pathway. Therefore we measured the expression, production of a few important extracellular matrix proteins after Decorin, TGFB1 stimulation, costimulation of HSCs and MFs. Materials and methods: Cultures of rat HSC and MF from passages 3, 8, 12 (P1–14) were treated and cotreated with Decorin…
