CareLit Fachartikel
Effect of alpha-lipoic acid on the porphyria cutanea tarda patients with type 2 diabetes mellitus and heavy drinkers
E Székely, K Szentmihályi, G Tasnádi, K Várnai, A Blázovics · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Dokument
964772
CareLit-ID
Jahr
2005
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ja
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Zusammenfassung
Introduction: PCT is a disorder of heme biosynthesis resulting from a decreased activity of uroporphyrinogen decarboxylase enzyme. Heme precursors, predominantly uroporphyrin accumulate in the blood, liver, urine, stool, and skin. Iron toxicity is associated with pathological free radical reactions. Alpha-lipoic acid is a coenzyme of pyruvate and alpha-ketoglutarate dehydrogenase. Alpha-lipoic acid showed protective effects against lipid peroxidation, protein carbonyl formation, NO and ONOO-. Aim: We investigated the effect of alpha-lipoic acid on porphyrin concentration and iron metabolism in PCT patients with…
Schlagworte
Blood
After
Diagnosis
Coenzyme
Diabetes Mellitus
Zeitschrift für Gastroenterologie
