The prevalence of hereditary nonpolyposis colorectal carcinoma in eastern Hungary, the importance of screening
M Tanyi, L Damjanovich · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is a disease inherited in an autosomal dominant fashion and characterized by an early onset and the occurrence of colorectal or, less frequently, gastric, urinary and gynecological cancers. The genetic background of the disease is verified. The screening protocol has been established based on the Amsterdam and Bethesda criterias. HNPCC is often present in patients under 50 years and is characterized by a regular appearance in the succeeding generations. The cancer is more frequently located in the proximal colon and the presence of synchronous or me…