Plasma homocysteine levels and genetic variants of homocysteine metabolism related genes confer no independent risk of vascular events in a German population
S Moskau, S Farmand, H Kölsch, M Boes, C Grothe, K Fließbach, U Harbrecht, C Pohl, T Klockgether, U Wüllner, M Linnebank · Aktuelle Neurologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Objective: An elevation of total plasma homocysteine (Hcys) levels has become generally accepted as risk factor for arterial and venous vascular disease. However, elevated Hcys levels may rather constitute a secondary phenomenon of disease than the cause. Patients and Methods: In the present study we investigated fasting total plasma Hcys levels and nine polymorphisms involved in Hcys metabolism together with carotid intima media thickness (IMT) as intermediate phenotype of atherosclerosis in 714 individuals of 187 families: 187 consecutive patients ascertained by clinical vascular disease and with proven caroti…
