CareLit Fachartikel

Microplasmin reduces microvascular damage and blood brain barrier disruption following experimental stroke

M.R Vosko, M Schubert, A Trinkl, J.M Stassen, M Dichgans, G.F Hamann · Aktuelle Neurologie · 2005 · Heft 10

Dokument
965118
CareLit-ID
Jahr
2005
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
M.R Vosko, M Schubert, A Trinkl, J.M Stassen, M Dichgans, G.F Hamann
Ausgabe
Heft 10 / 2005
Seiten
–
Erschienen: 2005-10-26 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2005-919693

Zusammenfassung

Microvascular basal lamina integrity plays an essential role in blood-brain barrier disturbances following ischemic stroke. About 9% of stroke patient treated with rt-PA experience a thrombolysis-related secondary intracerebral hemorrhage. There is a need to find alternative thrombolytic substances with reduced adverse effects. We examined the influence of microplasmin (recombinantly generated truncated plasmin with thrombolytic action) on microvascular damage, blood brain barrier disruption and amount of endogenous tPA and uPA after focal ischemia and reperfusion in the rat. Male whistar rats were subjected to…

Schlagworte

Blood-Brain Barrier Blood After Basal Ganglia Work Aktuelle Neurologie