Wireless capsule endoscopy compared to gastroduodenoscopy with histology for the diagnosis of acute intestinal graft versus host disease (GVHD)–a prospective trial

Aims: The small intestine is the most common location of intestinal GVHD. Esophagogastroduodenoscopy (EGD) with duodenal biopsies has the highest diagnostic sensitivity. However, jejunum and ileum are not accessable by regular endoscopy. In contrast, wireless capsule endoscopy (WCE) is a non-invasive imaging procedure offering complete evaluation of the small intestine. Aims: The aims of the study were to compare the diagnostic value of EGD with histology with the results of WCE in blood stem cell transplanted patients with acute intestinal symptoms and to analyse the appearance and distribution of acute intesti…