CareLit Fachartikel
Human intestinal epithelial cells enhance apoptosis of intraepithelial lymphocytes by soluble factors
W Reindl, RM Schmid, N Endres · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Dokument
965139
CareLit-ID
Jahr
2006
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Intestinal intraepithelial lymphocytes (IEL) are a population of mainly CD8 positive, cytotoxic cells, in daily contact with a vast variety of oral antigens. Therefore the proliferative activity of these cells has to be tightly controlled to avoid excessive immune response with consecutive mucosal damage. The aim of this study was to determine the role of mucosal epithelial cells (EC) as regulators of IEL activity. To elucidate the influence of EC on IEL proliferation we established an in vitro coculture system of native human IEL and EC. Methods: EC and IEL were isolated from human mucosal samples and separated…
Schlagworte
Apoptosis
Antibodies
Population
Aminosalicylic Acid
CD4-CD8 Ratio
Annexin V
Cytokines
Antigens
After
Zeitschrift für Gastroenterologie
