Prognostic Significance of Isolated Tumor Cells (ITC) in the Bone Marrow (BM) of Breast Cancer Patients During Recurrence-free Follow-up and Therapeutic Intervention with Zoledron…
B Rack, W Janni, C Schindlbeck, B Strobl, T Blankenstein, M Heinrigs, D Rjosk, H Sommer, K Friese · Zentralblatt für Gynäkologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Aims: If the persistence of ITC after adjuvant therapy is associated with risk for recurrence, it would be an indication to consider secondary adjuvant treatment. Cell-cycle independent agents might be effective in the elimination of dormant cells. Methods: We analyzed BM aspirates from 228 pts during recurrence-free follow-up at a median interval of 21.3mon after primary diagnosis. ITC were detected by monoclonal antibody A45-B/B3 against cytokeratin. Pts were followed for a median of 49.8mon. In a pilot study on 14 pts with evidence of persisting ITC, zoledronate was applied (4mg q4wx6mon, loading dose 8mg). P…
