Evidence of changes in functional spreading of neural information within the myenteric reflex by Cannabinoid-1 receptor activation

Background: Propulsion along the intestine appears to occur by the action of a series of local reflexes which cause oral contraction and anal relaxation of circular muscle. This is associated with typical electrophysiological changes. Aim: Aim of the study was to investigate influence of local electrical field stimulation (EFS) on gastrointestinal electrophysiology of murine large bowel using a 12 channel stimulation electrode in a newly designed model of the ascending peristaltic reflex with simultaneous intracellular recording. Methods: Isolated proximal colon without mucosa and submucosa was investigated. Ref…