New role for the hepatocyte during TGF-β mediated liver fibrogenesis
K Breitkopf, E Wiercinska, J Hamzavi, L Wickert, AM Gressner, S Kanzler, R Heuchel, MV Singer, S Dooley · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
The majority of chronic liver diseases are caused by alcohol and hepatotoxic viruses. These noxes lead to damage of liver cells and release of TGF-β. A central event of this process is transdifferentiation of hepatic stellate cells (HSC). We have previously shown that general hepatic overexpression of the TGF-β antagonist Smad7 abrogates development of experimentally induced fibrosis and inhibits HSC transdifferentiation in vitro. Aim of the present study was to delineate in more detail how Smad7 affects pro-fibrogenic signaling in the different liver cell types. As expected, Smad7 k.o. mice develop more severe…
