The novel gene MIA2 promotes progression of hepatocellular carcinoma
C Hellerbrand, T Amann, J Schlegel, T Spruss, F Bataille, A Hartmann, M Mühlbauer, J Schölmerich, A Bosserhoff · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
Recently, we characterized the novel, exclusively in hepatocytes expressed human gene MIA2 1 and demonstrated reduced or lost expression, respectively, of MIA2 in hepatocellular carcinoma (HCC) 2. Here, we aimed to analyze the role of MIA2 in HCC development and progression. Methods: MIA2 expression was re-induced in hepatoma cells by stable transfection with an MIA2 expression construct, and invasion assays were performed in comparison to mock transfected hepatoma cells. Moreover, growth of MIA2 and mock transfected cell clones was compared in vivo after subcutaneous implantation into nude mice. Furthermore, MI…
