Investigations into the receptor requirements of Hepatitis C Virus (HCV) pseudoparticles and cell culture grown virions
T von Hahn, M Flint, BD Lindenbach, A Boullier, O Quehenberger, CM Rice, JA McKeating · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction & Methods: The study of the cell entry of Hepatitis C Virus (HCV) into target cells had until recently been hampered by the lack of robust in vitro systems that model these first events in the viral lifecycle. A substantial advance was the arrival of HIV-based pseudoparticles bearing HCV glycoproteins (HCV pseudoparticles, HCVpp). Using HCVpp several groups have provided ample evidence that CD81, scavenger receptor BI (SR-BI) and very likely other as yet unidentified molecules are required to allow cell entry of incoming HCV. Now that besides HCVpp complete HCV virions grown in cell culture (HCVcc)…
