CareLit Fachartikel

Characterization of Matrix Metalloproteinase (MMP) expression and activity in the lungs of patients with Idiopathic Pulmonary Fibrosis (IPF)

T Nkyimbeng, C Ruppert, P Markart, M Korfei, R Schmidt, W Seeger, A Günther · Pneumologie · 2006 · Heft 04

Dokument
965564
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
T Nkyimbeng, C Ruppert, P Markart, M Korfei, R Schmidt, W Seeger, A Günther
Ausgabe
Heft 04 / 2006
Seiten
–
Erschienen: 2006-04-20 00:00:00
ISSN
0934-8387
DOI
10.1055/s-2006-933753

Zusammenfassung

Background: Matrix metalloproteinases (MMPs) are inducible zinc-dependent, secreted or cell surface endopeptidases that are centrally involved in extracellular matrix turnover. An imbalance of MMPs and their inhibitors (TIMPs) in the lung was recently suggested to contribute to the pathogenesis of interstitial lung diseases such as Idiopathic Pulmonary Fibrosis (IPF). Objective: In the present study we investigated the expression and activity of different MMPs and TIMP in the lungs of patients with IPF. Methods: Lung homogenates from IPF patients and healthy controls were analyzed for the expression and activity…

Schlagworte

Expression Activity Lungs Healthy Controls Observed Patients Could Matrix Contribute Different Analyzed Pneumologie