Brain structural alterations in Fabry disease: ROI-based and voxel-based analyses of diffusion tensor imaging parameters

Background: Fabry disease (FD) is a lysosomal storage disorder that is associated with marked cerebrovascular disease. Conventional MRI shows progressive load of white matter lesions (WMLs) due to cerebral vasculopathy in the course of FD. Objective: ROI based DTI analysis was performed on 27 clinically affected FD patients and 21 age-matched controls. Additionally, a subgroup of this collective (26 patients, 12 controls) was analised with voxel-based DTI. Methods: DTI was performed on a 1.5T system (Sonata, Siemens). ROIs were placed individually for patients and controls bilaterally in 7 visually unaffected wh…