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Effects of physiological aging and cerebrovascular risk factors on the hemodynamic response to brain activation: A functional transcranial Doppler study

K Gröschel, C Terborg, A Riecker, OW Witte, A Kastrup · Klinische Neurophysiologie · 2006 · Heft 03

Dokument
965632
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
K Gröschel, C Terborg, A Riecker, OW Witte, A Kastrup
Ausgabe
Heft 03 / 2006
Seiten
–
Erschienen: 2006-03-24 00:00:00
ISSN
1434-0275
DOI
10.1055/s-2006-939153

Zusammenfassung

Evidence is accumulating that aging can alter the coupling of the cerebral blood flow (CBF) to focal brain activation (neurovascular coupling). Aside from „true“ neurodegenerative causes, changes of the vascular system due to the presence of risk factors for an atherosclerosis could also be responsible for a decreased hemodynamic response during neuronal activation in old subjects. Assuming similarities between the mechanisms responsible for the coupling of CBF to neuronal activity and the increase of CBF during hypercapnia, the influence of the vascular system on the neurovascular coupling can indirectly be ass…

Schlagworte

Aging Atherosclerosis Cerebral Arteries Population Arteries Blood Klinische Neurophysiologie