Non-invasive recording of motor-related focal DC-changes in stroke patients using DC-Magnetoencephalography

Introduction: Slowly changing depolarisations of the cerebral gray matter are observed in border zones of cerebral ischemic foci. These slow potential shifts are referred to as periinfarct depolarisations (PID) and cortical spreading depressions (CSD). Up to now CSD in patients have been recorded solely invasively. In animal models, PID and CSD have been shown to cause infarct expansion. Experimental neuroprotection treatments were able to decrease the incidence of PID and CSD. For this reasons, non-invasive monitoring of slow cortical potentials would have an important prognostic and therapeutic impact. In this…