Increasing the validity of functional MRI for presurgical language lateralization: proposal for an algorithm
J Wellmer, J Wellmer, B Weber, F Mormann, S Weis, P Klaver, H Urbach, J Reul, J Ruhlmann, CE Elger, G Fernandez · Klinische Neurophysiologie · 2006 · Heft 03
Bibliografische Angaben
Zusammenfassung
Introduction: In the presurgical evaluation of epilepsy patients, functional MRI (fMRI) increasingly replaces the intracarotid amobarbital procedure (IAP) for language lateralization. However, recent studies reveal relevant discrepancy between both methods on the single patient level. This questions the uncritical application of fMRI as the only tool for language lateralization. Conditions have to be known, under which fMRI may lateralize language incorrectly. Materials and Methods: 238 patients received fMRI, 65 of them also IAP. By applying the criteria (1) absence of fMRI-interfering lesions, (2) sufficient p…
