Radiation pneumonitis in rat lung after treatment with rhenium-188-microspheres
K Liepe, M Haase, D Faulhaber, G Wunderlich, M Andreeff, W Dörr, R Jung, J Kotzerke · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2008 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: A therapeutic option in patients with primary or secondary liver cancer is the intra-arterial administration of radioactive particles. If the patients have a large liver to lung shunt, the lung is the dose limiting organ. Therefore, knowledge of the tolerable radiation absorbed dose to the lung (TRAD-L) is important. In this animal study, the TRAD-L was determined. Material and Methods: Different activities of rhenium-188 microspheres were injected i.v. through the tail vein of 59 albino Wistar rats (8±2 month old male rats of 413±22g weight). The rats were divided into 6 groups with a RAD-L of 0–1…
