Initial treatment with topiramate in hospitalised patients – a prospective, observational study

Rationale: To explore effectiveness outcomes of hospitalised patients with epileptic seizures treated with topiramate (TPM) Methods: Prospective observational study in hospitalised patients >12 years with epilepsy being evaluated in-house (visits V1-V3) and during an optional follow up visit. Seizure frequency, adverse events were documented. Results: 154 patients (53% male; mean age 61 years±19) were selected. 84% were treatment naïve. 81% with data from V4 continued on TPM. Mean age in treatment naïve patients was higher than in pretreated patients (63 years vs. 50 years, p