Proteome analysis of cerebrospinal fluid in patients with Multiple System Atrophy (MSA)

Background: Multiple system atrophy (MSA) is a degenerative neurological disorder which belongs to the synucleinopathies. As a Parkinson plus syndrome, MSA can be sub-grouped into a cerebellar subtype (MSA-c), a parkinsonian subtype (MSA-p) and an autonomic subtype (MSA-a), dependent on the brain area most affected. Differential diagnosis of MSA to other parkinsonian syndromes frequently is difficult especially in early disease stages. In order to identify candidate biomarkers to differentiate between MSA subtypes we analysed the cerebrospinal fluid (CSF) proteome profile of patients with MSA and controls. Metho…