Synchrotron Micro-CT Imaging of Fe and Ca in Atherosclerotic Lesions in ApoE-/-/LDL-/- Double Knockout Mice
AC Langheinrich, A Michniewicz, DG Sedding, G Walker, PE Beighley, WS Rau, SM Jorgensen, RM Bohle, EL Ritman · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2006 · Heft 05
Bibliografische Angaben
Zusammenfassung
Ziele: Using synchrotron-based micro-CT and synchrotron-based X-ray fluorescence microscopy, we investigated advanced atherosclerotic lesions in the aortas of apoE-/-/LDL-/- double knockout mice so as to evaluate the relationship between vasa vasorum (VV) neovascularization and the adventitial inflammatory process/consequences. Methode: Aortas from anesthetized male apoE-/-/LDL-/- (n=27) mice were infused in situ with Microfil, harvested and scanned with micro-CT. Results were complemented by a detailed histological plaque classification according to AHA guidelines. The spatial distribution and size of iron depo…