The role of cholecystokinin in the enhancement of postprandial insulin sensitivity

The mechanism of postprandial insulin sensitization first described by Lautt and co-workers as the HISS (hepatic insulin sensitizing substance) machinery is not completely understood. We therefore studied the initial step in this mechanism leading to enhanced sensitivity of the peripheral tissues to the hypoglycemic action of insulin. Whole body insulin sensitivity was determined by the rapid insulin sensitivity test (RIST) or hyperinsulinemic euglycemic glucose clamping (HEGC) both in fasted and fed animals. The effect of cholecystokinin (CCK) was studied by means of a non-selective inhibitor of CCK receptor di…