Proteinase-activated receptor-2 agonist induced visceral hyperalgesia is prevented by dexamethasone via regulation of colonic mast cells in rats

Low-grade inflammation may play a role in the pathogenesis of irritable bowel syndrome. The aim of this study was to evaluate if dexamethasone (DEX) treatment prevents proteinase-activated receptor-2 (PAR-2) activation induced visceral hyperalgesia in rats, and to determine the role of PAR-2 and colonic mast cells in the effect of corticosteroid therapy. Methods: Abdominal contractions provoked by rectal distension were recorded in rats. Changes in visceral hypersensitivity provoked by intracolonic administration of PAR-2 activating peptide (SLIGRL), colonic mucosal mast cell proteinase-II (RMCP-II) content, mas…