Toll-like receptor TLR2, TLR3 and TLR4 expression in active IBD
B Szebeni, M Mraz, G Veres, A Dezsőfi, Á Vannay, B Vásárhelyi, É Majorova, A Arató · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background: Chronic inflammation in inflammatory bowel disease (IBD) may result from exaggerated stimulation of the mucosal immune system by the endogenous luminal bacterial flora. Bacterial products are recognized by pattern recognition receptors (PRRs) like Toll-like receptors (TLRs), which are key regulators of the innate immune system. Aim: The aim of this study was to characterise the expression of TLR2, TLR3 and TLR4 in colonic biopsy samples taken from children with active IBD either freshly diagnosed (fd) or after relapse (r) on treatment and compared to controls. Methods: Colonic biopsy specimens were c…
