CareLit Fachartikel

The role of acidic and biliary reflux in the expression of cyclooxigenase-2 (COX-2) in Barrett metaplasia

T Wittmann, A Rosztóczy, F Izbéki, R Róka, K Vadászi, I Németh, L Tiszlavicz, B Bod, L Czakó, J Csanádi, K Csefkó, Zs F. Kiss, Cs Góg, J Hudák, K Intzédy, M Karácsony, J Kiss, G Kurucsai, Gy Lázár, Z Lénárt, K Lovik, T Molnár, F Nagy, J Náfrádi, L Oczella, T… · Zeitschrift für Gastroenterologie · 2006 · Heft 06

Dokument
966998
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
T Wittmann, A Rosztóczy, F Izbéki, R Róka, K Vadászi, I Németh, L Tiszlavicz, B Bod, L Czakó, J Csanádi, K Csefkó, Zs F. Kiss, Cs Góg, J Hudák, K Intzédy, M Karácsony, J Kiss, G Kurucsai, Gy Lázár, Z Lénárt, K Lovik, T Molnár, F Nagy, J Náfrádi, L Oczella, T…
Ausgabe
Heft 06 / 2006
Seiten
–
Erschienen: 2006-06-21 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2006-943523

Zusammenfassung

The increase of the COX-2 expression is known as an early step in the sequence of malignant transformations including Barrett's metaplasia and esophageal adenocarcinoma. The aim of the study was to evaluate the role of acidic and biliary reflux in the upregulation of COX-2 activity in patients with Barrett's esophagus. Patients, methods: Sixty patients (M/F 37/23, mean age 56(26–84) years) with endoscopic evidence for Barrett's esophagus were enrolled. The standard histological evaluation of the biopsy specimens was extended by COX-2 immunohistochemistry. The staining intensity was scored between 0 and 3 by two…

Schlagworte

Zeitschrift für Gastroenterologie