Control of macrophage TNFalpha expression through transcriptional co-factor RIP140

Accelerated atherosclerosis represents a hallmark of the metabolic syndrome as observed in insulin-restistant patients. Defects in lipid and cytokine metabolism in macrophages are critically linked to the initiation and progression of atherosclerosis. Given the importance for atherosclerotic lesion development during insulin resistance, this study aimed to explore the transcriptional regulation of pro-inflammatory cytokine production in macrophages. We were able to show that nuclear receptor co-factor RIP140 enhances cytokine tumor necrosis factor (TNF) alpha gene activity upon lipopolysaccharide (LPS)-mediated…