Metabolic decompensation in children with T1DM is associated with a disbalance of the leptin axis

Objective: Type1 diabetes mellitus (T1DM) is related with increased serum levels of the soluble leptin receptor (sOB-R) by a so far unknown cellular mechanism. The aim of our study was to investigate potential metabolic factors that may be associated with the sOB-R release from its membrane receptor. Methods: We studied 25 children (age range between 1.5 and 17.0 years) admitted to the hospital with new onset of T1DM. Blood samples were available from routine determinations at diagnosis before (n=25) and following the initiation of insulin treatment after 11.1±4.3 hours (mean±standard deviation, n=16) as well as…