Changes in brain protein-expression of chaperones after perinatal asphyxia in a rat model at different ages

Background: Perinatal asphyxia (PA) is a major determinant of neurological morbidity in the pediatric population. Animal studies focusing on the subacute sequelae have uncovered a variety of morphological, neurochemical, behavioral and cognitive changes following PA, including deficits of the protein synthetic machinery and aberrant expression of individual brain proteins. The developing brain is uniquely vulnerable to hypoxic-ischemic injury, with a complex evolution of injury that affords opportunities for intervention. Rationale: Chaperones have been studied for their potential to protect the brain from ische…