NSAIDS and induction of erosive esophagitis

Aims: Non-steroidal antiinflammatory drugs (NSAIDS) are known to induce lesions in the stomach and duodenum. The relationship between NSAIDS and erosive esophagitis (EE) is unclear. Methods: To investigate a possible relationship between NSAIDS use and the presence of EE, we conducted two studies: 1) retrosp. case-control study of 416 patients with full information about the dose and duration of aspirin and non-aspirin NSAIDS, unselected of symptoms. 2) prosp. study in 20 healthy volunteers (HV, normal baseline endoscopy, no hiatal hernia, H.pylori negative, refraining from alcohol, smoking, and other drug intak…