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The fraktalkine receptor CX3CR1 is associated with progression of liver fibrosis in patients with chronic hepatitis C

D Scholten, E Dahl, T Berg, C Hellerbrand, S Hillebrandt, R Weiskirchen, C Trautwein, F Lammert, HE Wasmuth · Zeitschrift für Gastroenterologie · 2006 · Heft 09

Dokument
967227
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Jahr
2006
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
D Scholten, E Dahl, T Berg, C Hellerbrand, S Hillebrandt, R Weiskirchen, C Trautwein, F Lammert, HE Wasmuth
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-19 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2006-950783

Zusammenfassung

Aims: CX3CR1 constitutes the receptor for the chemokine fraktalkine (CX3CL1) which is involved in the recruitment of immune cells to the inflamed liver. In acute liver injury, CX3CR1 has been shown to be expressed on hepatocytes and bile ducts. Recently, two novel non-synonymous single nucleotide polymorphisms (SNPs) that affect the binding of fraktalkine have been identified in CX3CR1. Aim: The aim of the current project was the analysis of CX3CR1 mRNA expression at different stages of chronic liver injury and the association of functional CX3CR1 polymorphisms with the stages of liver fibrosis in a cohort of pa…

Schlagworte

Zeitschrift für Gastroenterologie