TGF-β promotes oxidative stress during chronic liver damage by interfering with MEOS and ADH metabolising systems

Aims: Fibrogenesis process involves cytokines, oxidative stress and complex interactions between liver cells. The hepatotoxic effect during chronic alcohol comsumption results from activating the alcohol dehydrogenase ADH and microsomal ethanol oxidating system MEOS. TGF-β is induced in livers of patients with alcoholic cirrhosis, suggesting that it is involved in the development of alcohol-induced liver damage but the process details remain to be understood. Aims: Primary cultured mouse hepatocytes were used as a system to investigate a possible crosstalk between TGF-β signaling and alcohol damaging effects. Me…