Analysis of transforming growth factor-β1 gene polymorphisms in patients with Hepatitis C infection
S Mohren, S Mengsteab, AM Gressner, E Kühnen, U Drebber, HP Dienes, M Odenthal, R Weiskirchen · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Considerable attention is focused on polymorphisms in the TGF-β1 gene, a multifunctional cytokine that is a potential susceptibility and modifier gene of organ fibrosis, cancer, autoimmune and inflammatory diseases, keloid disease, and hypertrophic scarring. Recently, we described novel LightCycler-based methods facilitating the examination of the three known variants (Leu10Pro, Arg25Pro, Thr263Ile) in the coding region of the human TGF-β1 gene (TGFB1) and found that the presence of Pro either in codon 25 or 10 is associated with the inter-individual variability in developing more severe hepatic fibrosis during…
