B cell responses in HIV infection of the central nervous system
G. von Geldern, S. Cepok, T. Nolting, V. Grummel, H.P. Hartung, O. Adams, G. Arendt, B. Hemmer · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and Aim: Central nervous system (CNS) involvement is common in human immunodeficiency virus (HIV) infection. HIV-1 is a neurotropic virus which may early during the course of infection invade the CNS. As the CNS constitutes an immunologically protected compartment, neurological progression is possibly independent of systemic viral burden. Little is still known about the role of the immune system in controlling HIV infection in the brain. Although HIV infection of the CNS is frequently associated with intrathecal immunoglobulin (Ig) synthesis, and high Ig titers have been observed in the CSF, particula…
