Gap junctional coupling of radial glia-like precursor cells in the adult dentate gyrus

In the adult dentate gyrus (DG), one of the neurogenic regions in the mature brain, cells with a radial glia (RG)-like morphology represent the putative stem cells that can give rise to new neurons and glial cells. In the course of neurogenesis, RG-like cells divide to generate precursors expressing immature neuronal features. Epileptic seizures or ischemic insults strongly enhance the proliferative activity of RG-like cells while neuronal precursors are less affected. However, the reasons for the different sensitivity of these cell types to pathological insults are poorly understood. In contrast to precursors t…