IL-22 mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression
J Dambacher, F Beigel, K Zitzmann, T Olszak, T Prüfer, CJ Steib, M Storr, B Göke, H Diepolder, M Bilzer, CJ Auernhammer, S Brand · Zeitschrift für Gastroenterologie · 2006 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background/Aims: The interleukin (IL)-10 like cytokine IL-22 is produced by activated T cells. In this study, we analyzed the role of this cytokine system in hepatic cells. Methods: Expression studies were performed by RT-PCR and quantitative PCR. Signal transduction was analyzed by Western blot experiments and ELISA. Hepatocyte regeneration was studied in in vitro restitution assays. Results: Binding of IL-22 to its receptor complex expressed on human hepatic cells results in activation of MAP kinases, Akt and STAT proteins. IL-22 stimulates cell proliferation and migration which are both significantly inhibite…
