C-Fos Expression as Predictor of Progression and Survival in Epithelial Ovarian Carcinoma

Background Members of the Fos protein family dimerize with Jun proteins to form the AP–1 transcription factor complex. They play a central role in proliferation and differentiation of normal tissue as well as in oncogenic transformation and tumor progression. To investigate the role of Fos transcription factors in ovarian cancer, we analyzed the expression of c-Fos, FosB, Fra–1 and Fra–2 in patients with invasive epithelial ovarian carcinoma. Materials and Methods A total of 101 ovarian cancer patients who presented for initial surgery were included in the study. Protein expression was determined by Western Blot…